Arne Slot’s side host the La Liga club in an 8pm GMT kick-off at Anfield on Tuesday night.
After winning each of their first three meetings with Real, Liverpool have claimed victory in only one of the last nine – the 2-0 success at home in this competition last season.
That result at Anfield a year ago came thanks to second-half goals from Alexis Mac Allister and Cody Gakpo.This is the 10th time in the last 11 European campaigns that the Reds have faced Spanish opposition and the sixth Champions League season in a row that they have met a team from Madrid.
They have won four, drawn one and lost one in their last six fixtures against Spanish opponents at Anfield.
Liverpool are two goals short of registering 500 in the European Cup/Champions League.
Mohamed Salah is set to play his 200th game at Anfield for the Reds. He currently has 137 goals at home for the club.
Salah needs two more goals to become the first African to score 50 times in the Champions League.
Dominik Szoboszlai and Virgil van Dijk have played every minute of Liverpool’s Champions League campaign so far this season.
Conor Bradley will miss the home clash with PSV Eindhoven later this month if he is booked in this match.
Ibrahima Konate could play the 50th game in UEFA club competition of his career.
The Reds have had seven different scorers in Europe already this season, their most after three games since 1981-82 in the European Cup.
